Author: Nathalie Pamir; Calvin Pan; Deanna L. Plubell; Patrick M. Hutchins; Chongren Tang; Jake Wimberger; Angela Irwin; Thomas Q. de Aguiar Vallim; Jay W. Heinecke; Aldons J. Lusis
Title: Genetic control of the HDL proteome Document date: 2018_8_31
ID: hx7n4xfo_28
Snippet: In summary, a systems biology approach reveals the highly complex and inter-correlated nature of HDL protein composition, heritable contributions to both HDL levels and composition and its association with disease. We show that HDL proteins preserve hereditary patterns that are likely to harbor ancestral/lineage information. It is likely that inheritance controls the production of HDL particles of a certain protein and lipid composition that have.....
Document: In summary, a systems biology approach reveals the highly complex and inter-correlated nature of HDL protein composition, heritable contributions to both HDL levels and composition and its association with disease. We show that HDL proteins preserve hereditary patterns that are likely to harbor ancestral/lineage information. It is likely that inheritance controls the production of HDL particles of a certain protein and lipid composition that have different functions. At present, we lack a model for the assembly of HDL protein and lipid cargo. Our results provide the ground work to support future studies aimed at characterization of the genetic architecture regulating HDL function and comprehensive composition in humans.
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