Selected article for: "lopinavir ritonavir and low certainty"
Author: Verdugo-Paiva, Francisca; Izcovich, Ariel; Ragusa, Martin; Rada, Gabriel
Title: Lopinavir/ritonavir f​or the treatment of COVID-19: A living systematic review protocol
  • Cord-id: mhi6w4mr
  • Document date: 2020_4_17
    • ID: mhi6w4mr
    Snippet: Objective To assess the efficacy and safety of lopinavir/ritonavir for the treatment of patients with COVID-19. Design This is the protocol of a living systematic review. Data sources We will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature and in a centralised repository in L-OVE (Living OVerview of Evidence). L-OVE is a platform that maps PICO questions to evidence from Epistemonikos database. In response to the COVID-19 emer
    Document: Objective To assess the efficacy and safety of lopinavir/ritonavir for the treatment of patients with COVID-19. Design This is the protocol of a living systematic review. Data sources We will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature and in a centralised repository in L-OVE (Living OVerview of Evidence). L-OVE is a platform that maps PICO questions to evidence from Epistemonikos database. In response to the COVID-19 emergency, L-OVE was adapted to expand the range of evidence it covers and customised to group all COVID-19 evidence in one place. The search will cover the period until the day before submission to a journal. Eligibility criteria for selecting studies and methods We adapted an already published common protocol for multiple parallel systematic reviews to the specificities of this question. We will include randomised trials evaluating the effect of lopinavir/ritonavir - as monotherapy or in combination with other drugs - versus placebo or no treatment in patients with COVID-19. Randomised trials evaluating lopinavir/ritonavir in infections caused by other coronaviruses, such as MERS-CoV and SARS-CoV, and non-randomised studies in COVID-19 will be searched in case no direct evidence from randomised trials is found, or if the direct evidence provides low- or very low-certainty for critical outcomes. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will perform random-effects meta-analyses and use GRADE to assess the certainty of the evidence for each outcome. A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit it if the conclusions change or there are substantial updates. Ethics and dissemination No ethics approval is considered necessary. The results of this review will be widely disseminated via peer-reviewed publications, social networks and traditional media.

    Search related documents:
    Co phrase search for related documents
    • abstract title and additional search: 1, 2, 3, 4, 5
    • abstract title and lopinavir ritonavir: 1, 2
    • abstract title and lopinavir ritonavir combination: 1
    • active drug and administration route: 1, 2
    • active drug and liver disease: 1
    • active drug and lopinavir ritonavir: 1
    • active drug and lopinavir ritonavir combination: 1
    • administration route and lopinavir plus ritonavir: 1
    • administration route and lopinavir ritonavir: 1
    • administration route and lopinavir ritonavir combination: 1
    • administration route timing and lopinavir plus ritonavir: 1
    • administration route timing and lopinavir ritonavir: 1
    • administration route timing duration and lopinavir plus ritonavir: 1
    • administration route timing duration and lopinavir ritonavir: 1
    • administration route timing duration dosage and lopinavir plus ritonavir: 1
    • administration route timing duration dosage and lopinavir ritonavir: 1
    • liver disease and lopinavir plus ritonavir: 1
    • liver disease and lopinavir ritonavir: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18