Selected article for: "local immunity and lung damage"
Author: Guéant, Jean‐Louis; Guéant‐Rodriguez, Rosa‐Maria; Fromonot, Julien; Oussalah, Abderrahim; Louis, Huguette; Chery, Celine; Gette, Mickael; Gleye, Stanislas; Callet, Jonas; Raso, Jeremie; Blanchecotte, François; Lacolley, Patrick; Guieu, Régis; Regnault, Véronique
Title: Elastase and exacerbation of neutrophil innate immunity are involved in multi‐visceral manifestations of COVID‐19
  • Cord-id: pyaxnga9
  • Document date: 2021_2_27
    • ID: pyaxnga9
    Snippet: BACKGROUND: Many arguments suggest that neutrophils could play a prominent role in COVID‐19. However, the role of key components of neutrophil innate immunity in severe forms of COVID‐19 has deserved insufficient attention. We aimed to evaluate the involvement of neutrophil elastase, histone‐DNA, and DNases in systemic and multi‐organ manifestations of COVID‐19. METHODS: We performed a multicenter study of markers of neutrophil innate immunity in 155 cases consecutively recruited in a
    Document: BACKGROUND: Many arguments suggest that neutrophils could play a prominent role in COVID‐19. However, the role of key components of neutrophil innate immunity in severe forms of COVID‐19 has deserved insufficient attention. We aimed to evaluate the involvement of neutrophil elastase, histone‐DNA, and DNases in systemic and multi‐organ manifestations of COVID‐19. METHODS: We performed a multicenter study of markers of neutrophil innate immunity in 155 cases consecutively recruited in a screening center, local hospitals, and two regional university hospitals. The cases were evaluated according to clinical and biological markers of severity and multi‐organ manifestations and compared to 35 healthy controls. RESULTS: Blood neutrophil elastase, histone‐DNA, myeloperoxidase‐DNA, and free dsDNA were dramatically increased, and DNase activity was decreased by 10‐fold, compared with controls. Neutrophil elastase and histone‐DNA were associated with intensive care admission, body temperature, lung damage, and markers of cardiovascular outcomes, renal failure, and increased interleukin‐6 (IL‐6), IL‐8, and CXCR2. Neutrophil elastase was an independent predictor of the computed tomography score of COVID‐19 lung damage and the number of affected organs, in multivariate analyses. The increased blood concentrations of NE and neutrophil extracellular traps were related to exacerbation of neutrophil stimulation through IL‐8 and CXCR2 increased concentrations and increased serum DAMPs, and to impaired degradation of NETs as a consequence of the dramatic decrease in blood DNase activity. CONCLUSION: Our results point out the key role of neutrophil innate immunity exacerbation in COVID‐19. Neutrophil elastase and DNase could be potential biomarkers and therapeutic targets of severe systemic manifestations of COVID‐19.

    Search related documents:
    Co phrase search for related documents
    • absolute neutrophil count and acute respiratory distress syndrome: 1, 2, 3, 4, 5
    • absolute neutrophil count and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • absolute neutrophil count and logistic regression analysis: 1, 2, 3, 4, 5, 6, 7
    • absolute neutrophil count lactate dehydrogenase and acute ards respiratory distress syndrome: 1
    • absolute neutrophil count lactate dehydrogenase and acute respiratory distress syndrome: 1, 2, 3
    • absolute neutrophil count lactate dehydrogenase dimer and acute respiratory distress syndrome: 1, 2
    • activation neutrophil recruitment and acute ards respiratory distress syndrome: 1, 2, 3
    • activation neutrophil recruitment and acute respiratory distress syndrome: 1, 2, 3
    • active remain and acute respiratory distress syndrome: 1
    • active remain and logistic regression: 1, 2, 3
    • acute ards respiratory distress syndrome and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute ards respiratory distress syndrome and local hospital: 1, 2, 3, 4
    • acute ards respiratory distress syndrome and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute ards respiratory distress syndrome and logistic regression analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
    • acute ards respiratory distress syndrome and lung damage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute ards respiratory distress syndrome and lung viral infection: 1, 2, 3, 4, 5, 6, 7, 8
    • acute respiratory distress syndrome and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory distress syndrome and local hospital: 1, 2, 3, 4, 5, 6
    • acute respiratory distress syndrome and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25