Author: Mohammad Saeed; Alejandro Ibáñez-Costa; Alejandra María Patiño-Trives; Eduardo Collantes Estevez; María Ángeles Aguirre; Chary López-Pedrera
Title: Genomic convergence of locus-based GWAS meta-analysis identifies DDX11 as a novel Systemic Lupus Erythematosus gene Document date: 2020_4_18
ID: 27szdvgd_18
Snippet: Protein network analysis using STRING of 187 (55+132) genes with significant differential expression in GEO datasets showed a complex interaction network. DDX11 interacted indirectly with several genes that were found to be significant in OASIS loci and GEO datasets. DDX11 interaction with STAT1/STAT4 was mediated via RIF1, RBM25 and then BAZ1A ( Figure S1a ). Interaction analysis of 55 genes having significant differential expression in at least.....
Document: Protein network analysis using STRING of 187 (55+132) genes with significant differential expression in GEO datasets showed a complex interaction network. DDX11 interacted indirectly with several genes that were found to be significant in OASIS loci and GEO datasets. DDX11 interaction with STAT1/STAT4 was mediated via RIF1, RBM25 and then BAZ1A ( Figure S1a ). Interaction analysis of 55 genes having significant differential expression in at least 2 GEO datasets and with their expression directionally aligned, showed that DDX11 directly interacted with MED6 (interaction score 0.31) ( Figure S1b ). Interestingly, the remaining 132 genes included several known SLE genes such as IRF5, BLK, TNIP1 and CD44, however these genes were either significant in a single GEO dataset only or did not have a uniform up-/ down-regulation for the significant probes.
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