Selected article for: "candidate gene and multiple testing"
Author: Mohammad Saeed; Alejandro Ibáñez-Costa; Alejandra María Patiño-Trives; Eduardo Collantes Estevez; María Ángeles Aguirre; Chary López-Pedrera
Title: Genomic convergence of locus-based GWAS meta-analysis identifies DDX11 as a novel Systemic Lupus Erythematosus gene
  • Document date: 2020_4_18
    • ID: 27szdvgd_2
    Snippet: Genotyping a multitude of single-nucleotide polymorphisms (SNPs) in GWAS leads to the multiple testing problem, preventing the true association signal from being distinguished from random noise. Despite the identification of large number of genes in multiple comprehensive SLE GWAS and candidate gene studies, they together explain only 15% of SLE heritability (Bentham et al. 2015; Morris et al., 2016) ......
    Document: Genotyping a multitude of single-nucleotide polymorphisms (SNPs) in GWAS leads to the multiple testing problem, preventing the true association signal from being distinguished from random noise. Despite the identification of large number of genes in multiple comprehensive SLE GWAS and candidate gene studies, they together explain only 15% of SLE heritability (Bentham et al. 2015; Morris et al., 2016) .

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