Author: Yamano, Nozomi; Kunisada, Makoto; Nishiakiâ€Sawada, Aiko; Ohashi, Hiroyuki; Igarashi, Tatsushi; Nishigori, Chikako
Title: Evaluation of Acute Reactions on Mouse Skin Irradiated with 222 and 235 nm UVâ€C Cord-id: qecda0yg Document date: 2021_2_5
ID: qecda0yg
Snippet: Biological response and DNA damage following irradiation with shorter wavelengths in the UVâ€C range were evaluated to investigate the safety at three wavelengths because of the recent emergence of germicidal equipment emitting shortâ€wavelength UVâ€C for various purposes, including medical uses. To estimate an acceptable safety dose for human skin in the UVâ€C range, especially short UVâ€C, we studied the biological effects of 207, 222 and 235 nm UVâ€C using albino hairless mice and evalu
Document: Biological response and DNA damage following irradiation with shorter wavelengths in the UVâ€C range were evaluated to investigate the safety at three wavelengths because of the recent emergence of germicidal equipment emitting shortâ€wavelength UVâ€C for various purposes, including medical uses. To estimate an acceptable safety dose for human skin in the UVâ€C range, especially short UVâ€C, we studied the biological effects of 207, 222 and 235 nm UVâ€C using albino hairless mice and evaluated the inflammatory reactions in the skin. To explore an appropriate indicator to evaluate the biological response, we employed determination of the minimal perceptible response dose (MPRD), by which any subtle cutaneous response; erythema, edema and scale could be observed by visual inspection. Erythema was rarely observed, but edema and scale formation were evident for short UVâ€C wavelengths. The MPRD at 207, 222 and 235 nm was determined to be > 15, 15 and 2.0 kJ m(−2), respectively. These values could be thresholds and indicators for possible safety assessments. Our data suggest that the current human exposure limits for short UVâ€C wavelengths below 254 nm are overly restrictive and should be reconsidered for future disinfection lamps with short UVâ€C wavelengths.
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