Author: Mohammad Saeed; Alejandro Ibáñez-Costa; Alejandra María Patiño-Trives; Eduardo Collantes Estevez; María Ángeles Aguirre; Chary López-Pedrera
Title: Genomic convergence of locus-based GWAS meta-analysis identifies DDX11 as a novel Systemic Lupus Erythematosus gene Document date: 2020_4_18
ID: 27szdvgd_28
Snippet: This list of reference genes was tested in 3 GEO datasets (GSE30153, GSE13887, GSE10325) for expression. Two datasets (GSE30153, GSE13887) had SLE cases and healthy controls whereas GSE10325 had three cellular fractions (T, B cells and Monocytes) resulting in 3 additional datasets (GSE10325: T, B, M). A fourth geneexpression dataset, GSE50395, from Cordoba, Spain was used for validation (Perez-Sanchez et al, 2015) . However, the expression analys.....
Document: This list of reference genes was tested in 3 GEO datasets (GSE30153, GSE13887, GSE10325) for expression. Two datasets (GSE30153, GSE13887) had SLE cases and healthy controls whereas GSE10325 had three cellular fractions (T, B cells and Monocytes) resulting in 3 additional datasets (GSE10325: T, B, M). A fourth geneexpression dataset, GSE50395, from Cordoba, Spain was used for validation (Perez-Sanchez et al, 2015) . However, the expression analysis comparing SLE with healthy controls is new. Figure 1 details the methodology for gene discovery.
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