Author: Molina, MarÃa; Burgos, Elena; Cacho, Judit; Juega, Javier; Cañas, Laura; Taco, Omar; Perezpaya, Ines; Jou, Marina Urrutia; Martinez, Javier Paul; Graterol, Fredzzia; Lauzurica, Ricardo
Title: Routine biomarkers for the severity of COVID-19 pneumonia may present differently in kidney transplant recipients Cord-id: 9dnkm07a Document date: 2021_8_14
ID: 9dnkm07a
Snippet: Background The treatment of coronavirus disease (COVID-19) is based on the patient's clinical status and levels of inflammatory biomarkers. The comparative activity of these biomarkers in KT patients with COVID-19 pneumonia from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and non-SARS-CoV-2 aetiologies is unknown. Aim To compare the clinical presentation and inflammatory parameters at admission of KT patients with COVID-19 pneumonia and those with non-COVID-19 pneumonia over the
Document: Background The treatment of coronavirus disease (COVID-19) is based on the patient's clinical status and levels of inflammatory biomarkers. The comparative activity of these biomarkers in KT patients with COVID-19 pneumonia from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and non-SARS-CoV-2 aetiologies is unknown. Aim To compare the clinical presentation and inflammatory parameters at admission of KT patients with COVID-19 pneumonia and those with non-COVID-19 pneumonia over the same period. Methods Biomarkers were measured and compared between KT patients with COVID-19 pneumonia (n=57) and non-COVID-19 pneumonia (n=20) from March 2020 to March 2021. Results Both groups showed comparable demographics. The COVID-19 KT patients had fewer neutrophils (6,824 ± 5,000 vs. 8,969 ± 4,206, p = 0.09) than the non-COVID group, although there was no significant difference in the lymphocyte count. Non-COVID-19 pneumonia was associated with a higher d-dimer (921 [495-1,680] vs. 2,215 [879-3,934], p = 0.09) and IL-6 (35 [20-128] vs 222 [38-500], p = 0.006) levels. The ferritin level was higher in the COVID-19 group (809 [442-1,330] vs. 377 [276-885], p = 0.008). In multivariable analysis only d-dimer [HR:1 (1-1.002), p=0.02] and ferritin [HR:1 (0.9-0.9), p=0.02] rise the statistic signification. Conclusions COVID-19 pneumonia in KT recipients shows a different presentation of inflammatory biomarkers than other non-COVID pneumonias. It could be usefully to identify KT patients with COVID-19.More detailed studies are necessary to understand the presentation of biomarkers in KT with COVID-19.
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