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Author: Rusan, Maria; Ovesen, Thomas Oliver Kamarauskas; Fuursted, Kurt; Ovesen, Therese
Title: [The nose can be the focus of treatment and prophylactic approaches against COVID-19].
  • Cord-id: askevh1a
  • Document date: 2021_9_13
  • ID: askevh1a
    Snippet: Infection with SARS-CoV-2 frequently commences in the nasal cavity, yet knowledge about this initial virus-host interaction is sparse. In this review, we update our current understanding of SARS-CoV-2 infection via the nasal epithelium and the associated local immune response. Furthermore, we present considerations to how this interaction may influence the clinical course of COVID-19 and the systemic immune response, and lastly touch upon the potential for intranasal vaccination, intranasal anti
    Document: Infection with SARS-CoV-2 frequently commences in the nasal cavity, yet knowledge about this initial virus-host interaction is sparse. In this review, we update our current understanding of SARS-CoV-2 infection via the nasal epithelium and the associated local immune response. Furthermore, we present considerations to how this interaction may influence the clinical course of COVID-19 and the systemic immune response, and lastly touch upon the potential for intranasal vaccination, intranasal antiviral therapies and immunomodulatory approaches.

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