Author: Zhao, Yun-Li; Gou, Zhong-Ping; Shang, Jian-Hua; Li, Wan-Yi; Kuang, Yu; Li, Ming-Yuan; Luo, Xiao-Dong
Title: Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris Cord-id: qhitr4oq Document date: 2021_1_3
ID: qhitr4oq
Snippet: Alstonia scholaris could be used as a traditional medicinal plant in China for the treatment of acute respiratory, which might be caused by respiratory tract infections. The investigation tested the anti-infective effects of total alkaloids extract (TA) from leaves of A. scholaris, and as a result, TA inhibited herpes simplex virus type 1 (HSV-1), respiratory syncytial virus (RSV) and influenza A virus (H1N1) in vitro respectively. In addition, the survival days of mice were prolonged, and the l
Document: Alstonia scholaris could be used as a traditional medicinal plant in China for the treatment of acute respiratory, which might be caused by respiratory tract infections. The investigation tested the anti-infective effects of total alkaloids extract (TA) from leaves of A. scholaris, and as a result, TA inhibited herpes simplex virus type 1 (HSV-1), respiratory syncytial virus (RSV) and influenza A virus (H1N1) in vitro respectively. In addition, the survival days of mice were prolonged, and the lung weights and mortality of mice were decreased significantly, after oral administrated TA in H1N1 and beta-hemolytic streptococcus infectious models in vivo respectively. The finding supported partly the traditional usage of A. scholaris in the treatment of respiratory infections. [Image: see text] SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s13659-020-00294-6) contains supplementary material, which is available to authorized users.
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