Author: Rech, Lavinia; Rainer, Peter P.
Title: The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review Cord-id: uzzwwfk6 Document date: 2021_7_26
ID: uzzwwfk6
Snippet: Inflammation plays a central role in cardiovascular diseases (CVD). One pathway under investigation is the innate immune DNA sensor cyclic GMP-AMP synthase (cGAS) and its downstream receptor stimulator of interferon genes (STING). cGAS-STING upregulates type I interferons in response to pathogens. Recent studies show that also self-DNA may activate cGAS-STING, for instance, DNA released from nuclei or mitochondria during obesity or myocardial infarction. Here, we focus on emerging evidence descr
Document: Inflammation plays a central role in cardiovascular diseases (CVD). One pathway under investigation is the innate immune DNA sensor cyclic GMP-AMP synthase (cGAS) and its downstream receptor stimulator of interferon genes (STING). cGAS-STING upregulates type I interferons in response to pathogens. Recent studies show that also self-DNA may activate cGAS-STING, for instance, DNA released from nuclei or mitochondria during obesity or myocardial infarction. Here, we focus on emerging evidence describing the interaction of cGAS-STING with cardiovascular risk factors and disease. We also touch on translational therapeutic opportunities and potential further investigations.
Search related documents:
Co phrase search for related documents- adaptive innate and long period: 1
- adaptive innate and lps injection: 1
- adaptive innate and lupus erythematosus: 1, 2, 3, 4, 5, 6, 7
- adaptive innate and m1 macrophage: 1, 2
- adaptive innate response and adipose tissue: 1, 2, 3
- adaptive innate response and lupus erythematosus: 1
- adipose tissue and lupus erythematosus: 1, 2
- adipose tissue and m1 proinflammatory: 1
- lps induce and m1 macrophage: 1
Co phrase search for related documents, hyperlinks ordered by date