Author: Michael Jay Corley; Christopher Sugai; Michael Schotsaert; Robert E. Schwartz; Lishomwa C Ndhlovu
Title: Comparative in vitro transcriptomic analyses of COVID-19 candidate therapy hydroxychloroquine suggest limited immunomodulatory evidence of SARS-CoV-2 host response genes. Document date: 2020_4_14
ID: 30x26ip7_5
Snippet: Due to the immunomodulation effects reported HCQ [6] we surveyed whether in vitro treatment of peripheral blood mononuclear cells from healthy people with hydroxychloroquine (10 µM) impacted immune cell gene transcription. We used transcriptome profiling data from three heathy participants PBMC cells that had been either cultured ex vivo for 24 hours or treated with hydroxychloroquine for 24 hours (Supplemental Table 1 ). author/funder. All righ.....
Document: Due to the immunomodulation effects reported HCQ [6] we surveyed whether in vitro treatment of peripheral blood mononuclear cells from healthy people with hydroxychloroquine (10 µM) impacted immune cell gene transcription. We used transcriptome profiling data from three heathy participants PBMC cells that had been either cultured ex vivo for 24 hours or treated with hydroxychloroquine for 24 hours (Supplemental Table 1 ). author/funder. All rights reserved. No reuse allowed without permission.
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