Author: Burrell, Louise M.; Johnston, Colin I.; Tikellis, Christos; Cooper, Mark E.
Title: ACE2, a new regulator of the renin–angiotensin system Cord-id: autprmr4 Document date: 2004_3_27
ID: autprmr4
Snippet: Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the renin–angiotensin system (RAS). ACE2 is a newly described enzyme identified in rodents and humans with a more restricted distribution than ACE, and is found mainly in heart and kidney. ACE2 cleaves a single residue from angiotensin I (Ang I) to generate Ang 1–9, and degrades Ang II, the main effector of the RAS, to the vasodilator Ang 1–7. The importance of ACE2 in normal physiology and pathophysiolo
Document: Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the renin–angiotensin system (RAS). ACE2 is a newly described enzyme identified in rodents and humans with a more restricted distribution than ACE, and is found mainly in heart and kidney. ACE2 cleaves a single residue from angiotensin I (Ang I) to generate Ang 1–9, and degrades Ang II, the main effector of the RAS, to the vasodilator Ang 1–7. The importance of ACE2 in normal physiology and pathophysiological states is largely unknown. ACE2 might act in a counter-regulatory manner to ACE, modulating the balance between vasoconstrictors and vasodilators within the heart and kidney, and playing a significant role in regulating cardiovascular and renal function.
Search related documents:
Co phrase search for related documents- ace angiotensin convert enzyme and acute respiratory syndrome: 1
- ace catalytic domain and acute respiratory syndrome: 1
- ace compare and acute respiratory syndrome: 1, 2
- ace contrast and acute respiratory syndrome: 1
- ace human homologue and acute respiratory syndrome: 1, 2
- ace inhibition and acute respiratory syndrome: 1, 2, 3, 4, 5, 6
- ace inhibitor and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29
- ace inhibitor therapy and acute respiratory syndrome: 1, 2, 3, 4
- ace protein and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46
- ace protein and lung brain: 1, 2
- active enzymatic site and acute respiratory syndrome: 1
- acute respiratory syndrome and lung brain: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41
- acute respiratory syndrome and lung brain gastrointestinal tract: 1, 2
Co phrase search for related documents, hyperlinks ordered by date