Author: Lee, Yeong-Geun; Won Kang, Kyung; Hong, Woojae; Hwa Kim, Yeon; Taek Oh, Jen; Won Park, Dae; Ko, Minsung; Bai, Yun-Feng; Seo, Young-Jin; Lee, Sang-Myeong; Kim, Hyunggun; Chan Kang, Se
Title: Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2 Cord-id: 9hkh9871 Document date: 2021_7_23
ID: 9hkh9871
Snippet: Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-β-D-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-C
Document: Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-β-D-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants.
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