Selected article for: "primary endpoint and viral load"

Author: Maja von Cube; Marlon Grodd; Martin Wolkewitz; Derek Hazard; Jerome Lambert
Title: Harmonizing heterogeneous endpoints in COVID-19 trials without loss of information - an essential step to facilitate decision making
  • Document date: 2020_4_3
  • ID: bsddxgx2_8
    Snippet: The main part of the registered trials (n=9) uses a recovery outcome as primary endpoint. However, definition of recovery and duration of follow-up differ substantially between trials. Seven of these trials do not provide a precise clinical definition of their primary endpoint. Among those that provide more details, clinical recovery is defined in different ways. Follow-up in trials with recovery as endpoint ranges from 14 to 168 days with most t.....
    Document: The main part of the registered trials (n=9) uses a recovery outcome as primary endpoint. However, definition of recovery and duration of follow-up differ substantially between trials. Seven of these trials do not provide a precise clinical definition of their primary endpoint. Among those that provide more details, clinical recovery is defined in different ways. Follow-up in trials with recovery as endpoint ranges from 14 to 168 days with most trials (n=5) having a follow-up of 28 or 30 days. Generally, follow-up ranges from four to 168 days. Most trials (n=16) have a follow-up of 14 to 15 days (n=6 and 5 respectively) or 28 days (n=5). Other outcomes are discharge (n=1), clinical worsening (n=2), mortality (n=3) and viral load (n=3; this includes one study with two primary endpoints).

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