Author: Hong Zhou; Xing Chen; Tao Hu; Juan Li; Hao Song; Yanran Liu; Peihan Wang; Di Liu; Jing Yang; Edward C. Holmes; Alice C. Hughes; Yuhai Bi; Weifeng Shi
Title: A novel bat coronavirus reveals natural insertions at the S1/S2 cleavage site of the Spike protein and a possible recombinant origin of HCoV-19 Document date: 2020_3_5
ID: dbowa5bt_8
Snippet: whereas the pangolin beta-CoV from Guangdong had amino acid identity of 97.4% 7 , and was 118 the closest relative of HCoV-19 in this region. A similarity plot estimated using Simplot 10 also 119 revealed that RmYN02 was more similar to HCoV-19 than RaTG13 in most genome regions 120 (Fig. 1b) . Again, in the RBD, the pangolin/MP789/2019 virus shared the highest sequence 121 identity to HCoV-19 (Fig. 1c) . 122 123 Results from both homology modell.....
Document: whereas the pangolin beta-CoV from Guangdong had amino acid identity of 97.4% 7 , and was 118 the closest relative of HCoV-19 in this region. A similarity plot estimated using Simplot 10 also 119 revealed that RmYN02 was more similar to HCoV-19 than RaTG13 in most genome regions 120 (Fig. 1b) . Again, in the RBD, the pangolin/MP789/2019 virus shared the highest sequence 121 identity to HCoV-19 (Fig. 1c) . 122 123 Results from both homology modelling 1 , in vitro assays 2 and resolved three-dimensional 124 structure of the S protein 11 have revealed that like SARS-CoV, HCoV-19 could also use ACE2 125 as a cell receptor. We analyzed the RBD of RmYN02, RaTG13, and the two pangolin beta-126 CoVs using homology modelling (Fig. 2a-2f and Extended Data Figure 4 for sequence 127 author/funder. All rights reserved. No reuse allowed without permission.
Search related documents:
Co phrase search for related documents- amino acid and close relative: 1, 2, 3, 4, 5, 6
- amino acid and genome region: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51
- amino acid and Guangdong cov: 1, 2, 3, 4, 5, 6
- amino acid and high sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- amino acid and homology modelling: 1, 2, 3, 4, 5, 6, 7
- amino acid and pangolin virus: 1, 2, 3, 4, 5, 6, 7, 8, 9
- amino acid and similarity plot: 1, 2, 3
- amino acid identity and cell receptor: 1, 2, 3, 4
- amino acid identity and genome region: 1, 2, 3, 4, 5, 6, 7, 8
- amino acid identity and high sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- amino acid identity and homology modelling: 1
- amino acid identity and pangolin virus: 1, 2
- amino acid identity and similarity plot: 1
- cell receptor and close relative: 1, 2, 3
- cell receptor and genome region: 1
- cell receptor and high sequence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- close relative and genome region: 1, 2
- close relative and Guangdong cov: 1, 2
- close relative and high sequence: 1
Co phrase search for related documents, hyperlinks ordered by date