Author: So Young Kim; Weihua Jin; Amika Sood; David W. Montgomery; Oliver C. Grant; Mark M. Fuster; Li Fu; Jonathan S. Dordick; Robert J. Woods; Fuming Zhang; Robert J. Linhardt
Title: Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry Document date: 2020_4_15
ID: fs8dn7ir_24
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.041459 doi: bioRxiv preprint however, much more weakly with binding strengths of KD = 500 nM and 1 nM, respectively (Fig 2 and Table 1 ). While HS facilitates SARS-CoV host cell entry and is an essential host cell surface receptor, its involvement in MERS-CoV host cell entry or binding kinetics for SARS-Cov and MERS-CoV SGPs had not .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.041459 doi: bioRxiv preprint however, much more weakly with binding strengths of KD = 500 nM and 1 nM, respectively (Fig 2 and Table 1 ). While HS facilitates SARS-CoV host cell entry and is an essential host cell surface receptor, its involvement in MERS-CoV host cell entry or binding kinetics for SARS-Cov and MERS-CoV SGPs had not previously been reported [10] .
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