Author: Ella N Hartenian; Britt A Glaunsinger
Title: Herpesvirus infection reduces Pol II occupancy of host promoters but spares viral promoters Document date: 2019_3_26
ID: i51almnu_11
Snippet: we observed an RNA decay-induced repression of Pol II occupancy at the latent viral promoter 215 LANA while the viral K1 promoter was repressed in 4 out of 5 experiments ( Fig 5D) . We also 216 observed repression of the human Ef1a promoter, which is present on the KSHV viral episome 217 as a driver of the GFP reporter gene (Fig 5D) . In sum, these observations indicate that the viral 218 The copyright holder for this preprint (which was not peer.....
Document: we observed an RNA decay-induced repression of Pol II occupancy at the latent viral promoter 215 LANA while the viral K1 promoter was repressed in 4 out of 5 experiments ( Fig 5D) . We also 216 observed repression of the human Ef1a promoter, which is present on the KSHV viral episome 217 as a driver of the GFP reporter gene (Fig 5D) . In sum, these observations indicate that the viral 218 The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/585984 doi: bioRxiv preprint context and replication state, rather than promoter sequence, in determining the transcriptional 230 response to accelerated mRNA decay. 231
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