Author: Daniel J Butler; Christopher Mozsary; Cem Meydan; David C Danko; Jonathan Foox; Joel Rosiene; Alon Shaiber; Ebrahim Afshinnekoo; Matthew MacKay; Fritz J Sedlazeck; Nikolay A Ivanov; Maria A Sierra; Diana Pohle; Michael Zeitz; Vijendra Ramlall; Undina Gisladottir; Craig D Westover; Krista Ryon; Benjamin Young; Chandrima Bhattacharya; Phyllis Ruggiero; Bradley W Langhorst; Nathan A Tanner; Justyn Gawrys; Dmitry Meleshko; Dong Xu; Jenny Xiang; Angelika Iftner; Daniela Bezdan; John Sipley; Lin Cong; Arryn Craney; Priya Velu; Ari Melnick; Iman A Hajirasouliha; Thomas Iftner; Mirella Salvatore; Massimo Loda; Lars F Westblade; Shawn Levy; Melissa Cushing; Nicholas P Tatonetti; Marcin Imielinski; Hanna Rennert; Christopher Mason
Title: Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Document date: 2020_4_20
ID: kyoa5gsf_23
Snippet: A2a-25563 in NYC appeared to be consistently high across sampling dates, it constituted only a moderate proportion of cases from the Western USA (<50%) in early March with an increase (>78%) in late March (Figure 5d ). The SNV's defining this subclade were non-synonymous variants targeting genes encoding the non-structural protein 2 (NSP2), the viral replicase, and ORF3a, a poorly characterized SARS-CoV-2 protein with putative roles in inflammati.....
Document: A2a-25563 in NYC appeared to be consistently high across sampling dates, it constituted only a moderate proportion of cases from the Western USA (<50%) in early March with an increase (>78%) in late March (Figure 5d ). The SNV's defining this subclade were non-synonymous variants targeting genes encoding the non-structural protein 2 (NSP2), the viral replicase, and ORF3a, a poorly characterized SARS-CoV-2 protein with putative roles in inflammation (Siu et al., 2019) . This subclade defining ORF3a site (p.Gln57His) was distinct from that which defines the previously characterized L strain (p.Leu84Ser) (Tang et al., 2020) .
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