Author: Abdulrahman, Abdulkarim; Wael, Mohammed; AlAmmadi, Fajer; Almosawi, Zahra; Alsherooqi, Reem; Abduljalil, Manal; Kumar, Nitya; AlQahtani, Manaf
Title: Is sickle cell disease a risk factor for severe COVIDâ€19 outcomes in hospitalized patients? A multicenter national retrospective cohort study Cord-id: wj9la1jp Document date: 2021_2_10
ID: wj9la1jp
Snippet: INTRODUCTION: Studies that examine the association between sickle cell disease (SCD) and COVIDâ€19 outcomes are lacking. This study aims to determine whether SCD is a risk factor for severe COVIDâ€19 infection in regard to the requirement of noninvasive ventilation/high flow nasal cannula (NIV/HFNC), mechanical ventilation (MV), or death in hospitalized patients. METHODS: Retrospective cohort study included COVIDâ€19 patients admitted to four COVIDâ€19 treatment facilities in Bahrain between
Document: INTRODUCTION: Studies that examine the association between sickle cell disease (SCD) and COVIDâ€19 outcomes are lacking. This study aims to determine whether SCD is a risk factor for severe COVIDâ€19 infection in regard to the requirement of noninvasive ventilation/high flow nasal cannula (NIV/HFNC), mechanical ventilation (MV), or death in hospitalized patients. METHODS: Retrospective cohort study included COVIDâ€19 patients admitted to four COVIDâ€19 treatment facilities in Bahrain between February 24, 2020 and July 31, 2020. All SCD patients with COVIDâ€19 were included and compared to a randomly selected sample of nonâ€SCD patients with COVIDâ€19. Data were collected from the medical records. Multivariate logistic regression models were used to control for confounders and estimate the effect of SCD on the outcomes. RESULTS: 1792 patients with COVIDâ€19 were included; 38 of whom were diagnosed with SCD as well. In the SCD group, one (2.6%) patient required NIV/HFNC, one (2.6%) required MV, and one (2.6%) death occurred. In comparison, 56 (3.2%) of the nonâ€SCD patients required NIV/HFNC, 47 (2.7%) required MV, and death occurred in 58 (3.3%) patients. Upon adjusting for confounders, SCD had an odds ratio of 1.847 (95% CI: 0.39–8.83; p = 0.442). CONCLUSION: Our results indicate that SCD is not a risk factor for worse COVIDâ€19 outcomes in hospitalized patients.
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