Recent advances, approaches and challenges in targeting pathways for potential COVID-19 vaccines development

Calina, Daniela; Sarkar, Chandan; Arsene, Andreea Letitia; Salehi, Bahare; Docea, Anca Oana; Mondal, Milon; Islam, Muhammad Torequl; Zali, Alireza; Sharifi-Rad, Javad

During the COVID-19 pandemic in a modern era, there is a global consensus on the need for the rapid development of a vaccine against SARS-CoV-2 for effective and sustainable control. Developing these vaccines is fundamental to public health. This urgent need is supported by the scientific explosion in structural and genomic biology that facilitates the urgent development of an ideal COVID-19 vaccine, using new pathways to facilitate its large-scale development, testing, and manufacture. Here, we summarize the types of COVID-19 candidate vaccines, their current stage in early testing in human clinical trials, and the challenges for their implementation.