History of Coronary Heart Disease Increases the Mortality Rate of Coronavirus Disease 2019 (COVID-19) Patients: A Nested Case-Control Study Based on Publicly Reported Confirmed Cases in Mainland China

Tian Gu; Qiao Chu; Zhangsheng Yu; Botao Fa; Anqi Li; Lei Xu; Ruijun Wu; Yaping He

To fill the above research gaps in the existing literature about the morality risk factors for COVID-19, the present study conducted a nested case-control (NCC) study, aiming to evaluate the risk of the common pre-existing comorbidities (hypertension, coronary heart disease, diabetes and etc.) for mortality associated with COVID-19 in mainland China outside of Hubei Province. NCC, also called risk set sampling, has been widely used in studying the fatal disease risk effect in large pharmacoepidemiologic studies [23] [24] [25] [26] [27] [28] and risk prediction in pandemic influenza A (H1N1) 2009 (pH1N1) [29] . NCC is cost-effective in data collection, and is especially suitable for research on the death risk of diseases such as COVID-19, where the number of event-free people largely exceeds those who experienced events [30] . To attain this All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.