Selected article for: "gas exchange and respiratory failure"
Author: Poor, Hooman D.; Ventetuolo, Corey E.; Tolbert, Thomas; Chun, Glen; Serrao, Gregory; Zeidman, Amanda; Dangayach, Neha S.; Olin, Jeffrey; Kohli-Seth, Roopa; Powell, Charles A.
Title: COVID-19 Critical Illness Pathophysiology Driven by Diffuse Pulmonary Thrombi and Pulmonary Endothelial Dysfunction Responsive to Thrombolysis
  • Cord-id: tlxrvato
  • Document date: 2020_4_21
    • ID: tlxrvato
    Snippet: Critically ill COVID-19 patients have relatively well-preserved lung mechanics despite severe gas exchange abnormalities, a feature not consistent with classical ARDS but more consistent with pulmonary vascular disease. Patients with severe COVID-19 also demonstrate markedly abnormal coagulation, with elevated D-dimers and higher rates of venous thromboembolism. We present four cases of patients with severe COVID-19 pneumonia with severe respiratory failure and shock who demonstrated immediate i
    Document: Critically ill COVID-19 patients have relatively well-preserved lung mechanics despite severe gas exchange abnormalities, a feature not consistent with classical ARDS but more consistent with pulmonary vascular disease. Patients with severe COVID-19 also demonstrate markedly abnormal coagulation, with elevated D-dimers and higher rates of venous thromboembolism. We present four cases of patients with severe COVID-19 pneumonia with severe respiratory failure and shock who demonstrated immediate improvements in gas exchange and/or hemodynamics with systemic tPA.

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