Author: D’Ardes, Damiano; Carrarini, Claudia; Russo, Mirella; Dono, Fedele; Speranza, Rino; Digiovanni, Anna; Martinotti, Giovanni; Di Iorio, Angelo; Onofrj, Marco; Cipollone, Francesco; Bonanni, Laura
Title: Low molecular weight heparin in COVID-19 patients prevents delirium and shortens hospitalization Cord-id: snnpfqik Document date: 2020_11_13
ID: snnpfqik
Snippet: BACKGROUND: COVID-19 patients present with delirium during their hospitalization. AIMS: To assess the incidence of delirium in hospitalized COVID-19 patients and analyze the possible association with demographic, clinical, laboratory, and pharmacological factors. METHODS: COVID-19 patients were assessed for clinical signs of delirium and administered the assessment test for delirium and cognitive impairment (4AT) and the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) scales. R
Document: BACKGROUND: COVID-19 patients present with delirium during their hospitalization. AIMS: To assess the incidence of delirium in hospitalized COVID-19 patients and analyze the possible association with demographic, clinical, laboratory, and pharmacological factors. METHODS: COVID-19 patients were assessed for clinical signs of delirium and administered the assessment test for delirium and cognitive impairment (4AT) and the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) scales. RESULTS: Out of the 56 patients of our cohort, 14 (25.0%) experienced delirium. The use of low molecular weight heparin (LMWH) (enoxaparin 1 mg/kg/daily) was less frequent in patients with delirium (p = 0.004) and was accompanied by lower C reactive protein (CRP) levels (p = 0.006). DISCUSSION: The use of LMWH was associated with absence of delirium, independently of comorbidities and age. CONCLUSIONS: The use of LMWH may help preventing the occurrence of delirium in COVID-19 patients, with possible reduction of length of stay in the hospital and sequelae. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10072-020-04887-4.
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