P434 Factors associated with medical and psycosocioeconomic changes in IBD during the COVID-19 pandemic and post-pandemic period

Hu, S; Wang, X; Shen, B; Yu, Q; Zheng, J J; Chen, Y

BACKGROUND: The pandemic of COVID-19 had posed challenges in every aspect of the people’s life. COVID-19 had affected all age groups in both previously healthy individuals and those with chronic disease including IBD. This study aimed to investigate the occurrence and factors associated with psychosocioeconomical and medical changes in patients with IBD during the COVID-19 pandemic and post-pandemicperiod in China. METHODS: The survey questionnaires were sent to the patients with IBD in China including epicentres and outside. Bivariate analyses and logistic regression models were used to analysis associations between IBD and various demographic, disease factors, and patient-reported outcomes including working conditions, income, anxiety, stress, and sadness. RESULTS: Of the 2277 respondents, 144 (6.3%) respondents were from Hubei province which was the epicenter of COVID-19 in China. Multivariable regression demonstrated that patients had part-time work (odds ratio [OR]: 4.28; 95% confidence interval [CI]: 2.48-7.36; P<0.001) or those had middle education level (high school graduate and bachelor’s degree) (OR:7.28; 95%CI: 3.58-14.81; P<0.001) were more likely to have reduced income compared with those had full-time work or less than high school education level. In addition, female (OR: 1.41; 95%CI: 1.16-1.71; P= 0.01) patients were at higher risk of having an anxiety, stress and sadness disorder. While un-married patients (OR: 0.76; 95% CI: 0.63-0.91; P=0.003) patients were less likely to have mood changes. Moreover, IBD patients with active disease (OR: 4.79; 95% CI: 3.87-5.91; P<0.001) were at higher risk of IBD medication changes. CONCLUSION: The results from this large survey demonstrated that the COVID-19 pandemic affected the patients with IBD financially, psychosocially, and medically. Our findings highlighted the importance of screening for psychosocioeconomic and medical changes in patients with IBD, with particular attention to those of female sex, have part-time work, and active disease. Our IBD community needs to develop effective and feasible strategies to deal with current and future challenges such as a viral pandemic.