Rapid Response to Cytokine Storm Inhibition using Anakinra in a Patient with COVID-19 Myocarditis

Trpkov, Cvetan; MacMullan, Paul; Feuchter, Patricia; Kachra, Rahim; Heydari, Bobak; Merchant, Naeem; Bristow, Michael S.; White, James A.

A 62-year-old female with COVID-19 developed acute respiratory failure and cardiogenic shock in the setting of a systemic hyper-inflammatory state and apparent ST-elevation myocardial infarction. Cardiac magnetic resonance (CMR) imaging showed fulminant acute myocarditis with severe left ventricular dysfunction. Treatment with the recombinant interleukin-1 (IL-1) receptor antagonist anakinra and dexamethasone resulted in rapid clinical improvement, reduction in serum inflammatory markers and a marked recovery in CMR-based markers of inflammation and contractile dysfunction. The patient was subsequently discharged from hospital. Emerging evidence supports use of anti-inflammatory therapies, including anakinra and dexamethasone, in severe COVID-19.