P-084. Symptomatic SARS-COV-2 infected pregnant patients and preeclampsia: worse outcome?

Marins, Lina R; Erika,; Paniz, V; LR Oppermann, Maria; SG Quadro, Laiza; Vetorazzi, Janete; HM Costa, Sérgio; GL Ramos, José

Background/objectives: Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection and preeclampsia may share some common pathophysiological ground, as the inflammatory changes they impose. Although the clinical course of SARS COV-2 during pregnancy is not completely understood, recent findings suggest an increased risk of preeclampsia with severe features induced by viral infection. The aim of this study is to describe the clinical course of infected pregnant women who developed preeclampsia (PE). Methods: Cohort study of SARS-COV-2 PCR positive symptomatic pregnant patients, with (n=9) and without PE (n=45), followed from admission to hospital discharge. Clinical course, delivery, neonatal and maternal outcomes were analyzed. Results: SARS-Cov-2 women with PE had higher body mass index (41,3 ± 7,8kg/m2 vs 31,6 ± 6,2kg/m2;p<0,001) and higher level of d-dimers (3,47 ± 089 vs 1,97 ± 1,18;p 0,014) than their counterpart without PE. Delivery for maternal deterioration status was also more often in PE group (23,3% vs 75%;p 0,011). No differences were observed in rates of maternal intensive care admission, need of mechanical ventilation, pulmonary image findings, maternal oxygen saturation, gestational age of delivery or neonatal outcomes. Conclusions: Development of preeclampsia in symptomatic SARS-COV-2 infected pregnant women was associated with a higher rate of maternal-indicated deliveries. No differences were found regarding neonatal or maternal clinical outcomes.