Author: lianhua dong; Junbo Zhou; Chunyan Niu; Quanyi Wang; Yang Pan; Xia Wang; Yongzhuo zhang; Jiayi yang; Manqing Liu; Yang zhao; Tao peng; Jie xie; yunhua gao; Di wang; yun zhao; Xinhua Dai; xiang fang
Title: Highly accurate and sensitive diagnostic detection of SARS-CoV-2 by digital PCR Document date: 2020_3_18
ID: aa7slcnc_28
Snippet: Furthermore, among the 16 specimens corrected by RT-dPCR, 6 persons (P14,18-21and P23 in Supplemental Table 5 ) were directed for secondary testing following an initial negative test 2 to 10 days prior. Based on RT-qPCR results, further isolation and observation was still needed to be conducted as the testing result is suspect or negative and no clinical symptoms were observed for them. However, if based on RT-dPCR, all the six patients can be di.....
Document: Furthermore, among the 16 specimens corrected by RT-dPCR, 6 persons (P14,18-21and P23 in Supplemental Table 5 ) were directed for secondary testing following an initial negative test 2 to 10 days prior. Based on RT-qPCR results, further isolation and observation was still needed to be conducted as the testing result is suspect or negative and no clinical symptoms were observed for them. However, if based on RT-dPCR, all the six patients can be diagnosed with COVD-19 infected by SARS-CoV-2 and treatment could be conducted earlier. This indicates RT-dPCR is more sensitive and suitable for low viral load specimens from the patients under isolation and observation without clinical symptoms, which is in agreement with the very recent online report (18).
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