Author: Masre, Siti Fathiah; Jufri, Nurul Farhana; Ibrahim, Farah Wahida; Abdul Raub, Sayyidi Hamzi
Title: Classical and alternative receptors for SARSâ€CoVâ€2 therapeutic strategy Cord-id: b9palezs Document date: 2020_12_26
ID: b9palezs
Snippet: Understanding the molecules that are essential for severe acute respiratory syndrome coronavirusâ€2 (SARSâ€CoVâ€2) entry can provide insights into viral infection and dissemination. Recently, it has been identified from several studies that angiotensinâ€converting enzyme 2 receptor and transmembrane serine protease 2 are the main entry molecules for the SARSâ€CoVâ€2, which produced the pandemic of Covidâ€19. However, additional evidence showed several other viral receptors and cellular pr
Document: Understanding the molecules that are essential for severe acute respiratory syndrome coronavirusâ€2 (SARSâ€CoVâ€2) entry can provide insights into viral infection and dissemination. Recently, it has been identified from several studies that angiotensinâ€converting enzyme 2 receptor and transmembrane serine protease 2 are the main entry molecules for the SARSâ€CoVâ€2, which produced the pandemic of Covidâ€19. However, additional evidence showed several other viral receptors and cellular proteases that are also important in facilitating viral entry and transmission in the target cells. In this review, we summarized the types of SARSâ€CoVâ€2 entry molecules and discussed their crucial roles for virus binding, protein priming and fusion to the cellular membrane important for SARSâ€CoVâ€2 infection.
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