Author: Kumar, D.; Ferreira, V. H.; Chruscinski, A.; Kulasingam, V.; Pugh, T. J.; Dus, T.; Wouters, B.; Oza, A.; Ierullo, M.; Ku, T. J. Y.; Majchrzak-Kita, B.; Humar, S.; Bahinskaya, I.; Pinzon, N.; Zhang, J.; Heisler, L. E.; Krzyzanowksi, P.; Lam, B.; Lungu, I. M.; Garrels, M.; Mazzulli, T.; Cybulsky, M.; Humar, A.
Title: Prospective Observational Study of Screening Asymptomatic Healthcare Workers for SARS-CoV-2 at a Canadian Tertiary Care Center Cord-id: wvm0f5tc Document date: 2020_7_25
ID: wvm0f5tc
Snippet: We screened three separate cohorts of healthcare workers for SARS-CoV-2 via nasopharyngeal swab PCR. A seroprevalence analysis using multiple assays was performed in a subgroup. The asymptomatic health care worker cohorts had a combined positivity rate of 29/5776 (0.50%, 95%CI 0.32-0.75) compared to the symptomatic cohort rate of 54/1597 (3.4%) (ratio of symptomatic to asymptomatic 6.8:1). Sequencing demonstrated several variants. The seroprevalence (n=996) was 1.4-3.4% depending on assay. Prote
Document: We screened three separate cohorts of healthcare workers for SARS-CoV-2 via nasopharyngeal swab PCR. A seroprevalence analysis using multiple assays was performed in a subgroup. The asymptomatic health care worker cohorts had a combined positivity rate of 29/5776 (0.50%, 95%CI 0.32-0.75) compared to the symptomatic cohort rate of 54/1597 (3.4%) (ratio of symptomatic to asymptomatic 6.8:1). Sequencing demonstrated several variants. The seroprevalence (n=996) was 1.4-3.4% depending on assay. Protein microarray analysis showed differing SARS-CoV-2 protein reactivities and helped define likely true positives vs. suspected false positives. Routine screening of asymptomatic health care workers helps identify a significant proportion of infections.
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