Author: Courtney R. Sullivan; Catharine A. Mielnik; Sinead M. O’Donovan; Adam J. Funk; Eduard Bentea; Erica A.K. DePasquale; Zhexing Wen; Vahram Haroutunian; Pavel Katsel; Amy J. Ramsey; Jarek Meller; Robert E. McCullumsmith
Title: Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments Document date: 2018_6_5
ID: ltb6l5xz_12
Snippet: We also assessed the effects of antipsychotics on PFKL and GPI across multiple brain regions in the Stanley Medical Research Institute genomics database and detected an effect on GPI (p=0.006, fold change=1.09), but not PFKL (p=0.09, fold change=1.06). However, this effect was in the opposite direction of our findings, suggesting the decreased expression in pyramidal neurons in schizophrenia is not due to a medication effect. Additionally, we ass.....
Document: We also assessed the effects of antipsychotics on PFKL and GPI across multiple brain regions in the Stanley Medical Research Institute genomics database and detected an effect on GPI (p=0.006, fold change=1.09), but not PFKL (p=0.09, fold change=1.06). However, this effect was in the opposite direction of our findings, suggesting the decreased expression in pyramidal neurons in schizophrenia is not due to a medication effect. Additionally, we assessed the effects of ethanol use, smoking, and laterality on our dependent measures in schizophrenia subjects via secondary analyses of schizophrenia subjects on and off ethanol, smokers/nonsmokers, and left/right brain and did not detect any effects ( Figure S2 , panels C-H).
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