Selected article for: "different severity and severe infection"
Author: Zheng, Hong; Rao, Aditya M.; Dermadi, Denis; Toh, Jiaying; Murphy Jones, Lara; Donato, Michele; Liu, Yiran; Su, Yapeng; Dai, Cheng L.; Kornilov, Sergey A.; Karagiannis, Minas; Marantos, Theodoros; Hasin-Brumshtein, Yehudit; He, Yudong D.; Giamarellos-Bourboulis, Evangelos J.; Heath, James R.; Khatri, Purvesh
Title: Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses
  • Cord-id: bacli5vi
  • Document date: 2021_3_24
    • ID: bacli5vi
    Snippet: Viral infections induce a conserved host response distinct from bacterial infections. We hypothesized that the conserved response is associated with disease severity and is distinct between patients with different outcomes. To test this, we integrated 4,780 blood transcriptome profiles from patients aged 0 to 90 years infected with one of 16 viruses, including SARS-CoV-2, Ebola, chikungunya, and influenza, across 34 cohorts from 18 countries, and single-cell RNA sequencing profiles of 702,970 im
    Document: Viral infections induce a conserved host response distinct from bacterial infections. We hypothesized that the conserved response is associated with disease severity and is distinct between patients with different outcomes. To test this, we integrated 4,780 blood transcriptome profiles from patients aged 0 to 90 years infected with one of 16 viruses, including SARS-CoV-2, Ebola, chikungunya, and influenza, across 34 cohorts from 18 countries, and single-cell RNA sequencing profiles of 702,970 immune cells from 289 samples across three cohorts. Severe viral infection was associated with increased hematopoiesis, myelopoiesis, and myeloid-derived suppressor cells. We identified protective and detrimental gene modules that defined distinct trajectories associated with mild versus severe outcomes. The interferon response was decoupled from the protective host response in patients with severe outcomes. These findings were consistent, irrespective of age and virus, and provide insights to accelerate the development of diagnostics and host-directed therapies to improve global pandemic preparedness.

    Search related documents:
    Co phrase search for related documents
    • active role and acute ards respiratory distress syndrome: 1, 2, 3, 4
    • active role and acute infection: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • active role and acute sars respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
    • active role and acute viral infection: 1
    • active role and adaptive immune response: 1
    • active role and low expression: 1
    • active role and lymphoid cell: 1
    • active role and m1 macrophage: 1
    • active viral infection and acute infection: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • active viral infection and acute sars respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8
    • active viral infection and acute viral infection: 1, 2
    • active viral infection and low expression: 1
    • acute ards respiratory distress syndrome and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • acute ards respiratory distress syndrome and additional cohort: 1, 2
    • acute ards respiratory distress syndrome and low correlation: 1
    • acute ards respiratory distress syndrome and low density: 1, 2, 3, 4, 5, 6, 7
    • acute ards respiratory distress syndrome and low expression: 1, 2, 3, 4, 5, 6, 7
    • acute ards respiratory distress syndrome and lymphoid cell: 1