Selected article for: "hoc analysis and post hoc analysis"
Author: Daniel J Butler; Christopher Mozsary; Cem Meydan; David C Danko; Jonathan Foox; Joel Rosiene; Alon Shaiber; Ebrahim Afshinnekoo; Matthew MacKay; Fritz J Sedlazeck; Nikolay A Ivanov; Maria A Sierra; Diana Pohle; Michael Zeitz; Vijendra Ramlall; Undina Gisladottir; Craig D Westover; Krista Ryon; Benjamin Young; Chandrima Bhattacharya; Phyllis Ruggiero; Bradley W Langhorst; Nathan A Tanner; Justyn Gawrys; Dmitry Meleshko; Dong Xu; Jenny Xiang; Angelika Iftner; Daniela Bezdan; John Sipley; Lin Cong; Arryn Craney; Priya Velu; Ari Melnick; Iman A Hajirasouliha; Thomas Iftner; Mirella Salvatore; Massimo Loda; Lars F Westblade; Shawn Levy; Melissa Cushing; Nicholas P Tatonetti; Marcin Imielinski; Hanna Rennert; Christopher Mason
Title: Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
  • Document date: 2020_4_20
    • ID: kyoa5gsf_30
    Snippet: In a multivariate analysis that included age, sex, and IL-6 levels, a significant association between exposure to ACEIs and those requiring mechanical respiration was also found (HR=1.83 95%CI: 1.39-2.40, p=1.27E -05 ). Additionally, this association held when correcting for previously reported risk factors for SARS-CoV-2 morbidity and mortality with an HR=1.56 95%CI: 1.18-2.07, p=1.83E -03 (Supp. Figure 12a) . Moreover, we confirmed previously r.....
    Document: In a multivariate analysis that included age, sex, and IL-6 levels, a significant association between exposure to ACEIs and those requiring mechanical respiration was also found (HR=1.83 95%CI: 1.39-2.40, p=1.27E -05 ). Additionally, this association held when correcting for previously reported risk factors for SARS-CoV-2 morbidity and mortality with an HR=1.56 95%CI: 1.18-2.07, p=1.83E -03 (Supp. Figure 12a) . Moreover, we confirmed previously reported risk factors for both mechanical respiration and mortality. For requirement of mechanical respiration, we found significant effects from male sex (p=6.18E -03 ), diabetes (p=1.00E -03 ), and IL-6 (p=5.85E -113 ). In addition, for mortality we found significant effects from age (p=8.05E -72 ), male sex (p=6.13E -04 ), diabetes (p=6.66E -05 ), and IL-6 (p=1.26E -12 ). Finally, in a post-hoc comparative analysis between specific ACEIs, we found that benazepril was associated with significantly increased risk of mortality (N=32, HR=2.37 95%CI: 1.05-5.35, p=3.70E -02 ) (Supp. Figure 12b ).

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