Author: Harvala, Heli; Mehew, Jennifer; Robb, Matthew L; Ijaz, Samreen; Dicks, Steven; Patel, Monika; Watkins, Nicholas; Simmonds, Peter; Brooks, Tim; Johnson, Rachel; Gopal, Robin; Roberts, David J; Zambon, Maria; Thomas, Stephen; MacLennan, Sheila; Estcourt, Lise; Brailsford, Su; Baklan, Hatice; Tettmar, Kate; Kellington, Jeremy; Sell, Joanne; Miflin, Gail
Title: Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England, 22 April to 12 May 2020 Cord-id: uc316ncl Document date: 2020_7_16
ID: uc316ncl
Snippet: Serological reactivity was analysed in plasma from 436 individuals with a history of disease compatible with COVID-19, including 256 who had been laboratory-confirmed with SARS-CoV-2 infection. Over 99% of laboratory-confirmed cases developed a measurable antibody response (254/256) and 88% harboured neutralising antibodies (226/256). Antibody levels declined over 3 months following diagnosis, emphasising the importance of the timing of convalescent plasma collections. Binding antibody measureme
Document: Serological reactivity was analysed in plasma from 436 individuals with a history of disease compatible with COVID-19, including 256 who had been laboratory-confirmed with SARS-CoV-2 infection. Over 99% of laboratory-confirmed cases developed a measurable antibody response (254/256) and 88% harboured neutralising antibodies (226/256). Antibody levels declined over 3 months following diagnosis, emphasising the importance of the timing of convalescent plasma collections. Binding antibody measurements can inform selection of convalescent plasma donors with high neutralising antibody levels.
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