Selected article for: "immune response and intestinal immune response"
Author: Pascoal, Lívia Bitencourt; Rodrigues, Patrícia Brito; Genaro, Lívia Moreira; Gomes, Arilson Bernardo dos Santos Pereira; Toledo-Teixeira, Daniel Augusto; Parise, Pierina Lorencini; Bispo-Dos-Santos, Karina; Simeoni, Camila Lopes; Guimarães, Paula Veri; Buscaratti, Lucas Ildefonso; Elston, João Gabriel De Angeli; Marques-Souza, Henrique; Martins-de-Souza, Daniel; Ayrizono, Maria De Lourdes Setsuko; Velloso, Lício Augusto; Proenca-Modena, José Luiz; Moraes-Vieira, Pedro Manoel Mendes; Mori, Marcelo Alves Silva; Farias, Alessandro Santos; Vinolo, Marco Aurélio Ramirez; Leal, Raquel Franco
Title: Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples
  • Cord-id: 9vkdn8rk
  • Document date: 2021_2_8
    • ID: 9vkdn8rk
    Snippet: Microbiota-derived molecules called short-chain fatty acids (SCFAs) play a key role in the maintenance of the intestinal barrier and regulation of immune response during infectious conditions. Recent reports indicate that SARS-CoV-2 infection changes microbiota and SCFAs production. However, the relevance of this effect is unknown. In this study, we used human intestinal biopsies and intestinal epithelial cells to investigate the impact of SCFAs in the infection by SARS-CoV-2. SCFAs did not chan
    Document: Microbiota-derived molecules called short-chain fatty acids (SCFAs) play a key role in the maintenance of the intestinal barrier and regulation of immune response during infectious conditions. Recent reports indicate that SARS-CoV-2 infection changes microbiota and SCFAs production. However, the relevance of this effect is unknown. In this study, we used human intestinal biopsies and intestinal epithelial cells to investigate the impact of SCFAs in the infection by SARS-CoV-2. SCFAs did not change the entry or replication of SARS-CoV-2 in intestinal cells. These metabolites had no effect on intestinal cells’ permeability and presented only minor effects on the production of anti-viral and inflammatory mediators. Together our findings indicate that the changes in microbiota composition of patients with COVID-19 and, particularly, of SCFAs do not interfere with the SARS-CoV-2 infection in the intestine.

    Search related documents:
    Co phrase search for related documents
    • abdominal pain and acute respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
    • abdominal pain vomiting and absence presence: 1, 2, 3, 4
    • abdominal pain vomiting and acute respiratory distress syndrome: 1, 2, 3, 4, 5, 6
    • abdominal pain vomiting diarrhea and absence presence: 1
    • abdominal pain vomiting diarrhea and acute respiratory distress syndrome: 1, 2
    • absence presence and acute respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
    • absence presence and lung epithelial cell: 1
    • acute respiratory distress syndrome and lung epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15