Author: Aleksandra Milewska; Ying Chi; Artur Szczepanski; Emilia Barreto-Duran; Kevin Liu; Dan Liu; Xiling Guo; Yiyue Ge; Jingxin Li; Lunbiao Cui; Marek Ochman; Maciej Urlik; Sylwia Rodziewicz-Motowidlo; Fengcai Zhu; Krzysztof Szczubialka; Maria Nowakowska; Krzysztof Pyrc
Title: HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV Document date: 2020_3_31
ID: 86stuueg_1
Snippet: Coronaviruses mainly cause respiratory and enteric diseases in humans, other mammals, 50 and birds. However, some species can cause more severe conditions such as hepatitis, 51 peritonitis, or neurological disease. Seven coronaviruses infect humans, four of which (human pangolins were suggested as such 9 . The virus is associated with a respiratory illness that, in a 63 proportion of cases, is severe. The mortality rate varies between locations, .....
Document: Coronaviruses mainly cause respiratory and enteric diseases in humans, other mammals, 50 and birds. However, some species can cause more severe conditions such as hepatitis, 51 peritonitis, or neurological disease. Seven coronaviruses infect humans, four of which (human pangolins were suggested as such 9 . The virus is associated with a respiratory illness that, in a 63 proportion of cases, is severe. The mortality rate varies between locations, but at present, is 64 estimated to reach 3-4% globally. The virus infects primarily ciliated cells and type II severity varying from asymptomatic to potentially fatal acute respiratory distress [14] [15] [16] . To date, 74 MERS-CoV infection was confirmed in 27 countries, with over 2,000 cases and a mortality rate 75 of ~35%. 76 Currently, there are no vaccines or drugs with proven efficacy to treat coronavirus 77 infection, and treatment is limited to supportive care. However, a range of therapeutics have Consequently, broad-spectrum antivirals are essential in long-term perspective. we dissected the mechanism of the HTCC antiviral activity. We showed that the polymer 96 interacts with the coronaviral Spike (S) protein and blocks its interaction with the cellular 97 receptor 22-24 . Here, we analyzed the HTCC activity against SARS-CoV-2 and MERS-CoV in 98 author/funder. All rights reserved. No reuse allowed without permission.
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