HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV

Aleksandra Milewska; Ying Chi; Artur Szczepanski; Emilia Barreto-Duran; Kevin Liu; Dan Liu; Xiling Guo; Yiyue Ge; Jingxin Li; Lunbiao Cui; Marek Ochman; Maciej Urlik; Sylwia Rodziewicz-Motowidlo; Fengcai Zhu; Krzysztof Szczubialka; Maria Nowakowska; Krzysztof Pyrc

The active compound 257 The HTCC was prepared in the same manner as previously described 22,23,28 . The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.29.014183 doi: bioRxiv preprint sequence verified that was a gift from Xingchuan Huang. psPAX (Addgene plasmid # 12260) 263 and pMD2G (Addgene plasmid # 12259) was a gift from Didier Trono. Lego-G2 vector 264 (Addgene plasmid #25917) was a gift from Boris Fehs. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.29.014183 doi: bioRxiv preprint Cell viability assay 287 HAE cultures were prepared as described above. Cell viability assay was performed by (TPP) were exposed to MERS-CoV, SARS-CoV-2 or mock at a TCID50 of 400 per ml in the 311 author/funder. All rights reserved. No reuse allowed without permission.