Author: Eric W. Stawiski; Devan Diwanji; Kushal Suryamohan; Ravi Gupta; Frederic A. Fellouse; J. Fah Sathirapongsasuti; Jiang Liu; Ying-Ping Jiang; Aakrosh Ratan; Monika Mis; Devi Santhosh; Sneha Somasekar; Sangeetha Mohan; Sameer Phalke; Boney Kuriakose; Aju Antony; Jagath R. Junutula; Stephan C. Schuster; Natalia Jura; Somasekar Seshagiri
Title: Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility Document date: 2020_4_10
ID: jfdshwfh_8
Snippet: As the interactions between the ACE2 receptor and S-protein RBD interface are critical for the cellular entry of the virus, we wondered if there were natural ACE2 variations that decrease or increase its affinity to the S-protein RBD that may protect or render individuals more susceptible to the virus. Consistent with this possibility, a saturation mutagenesis screen of select ACE2 PD residues identified variants that showed enhanced or decreased.....
Document: As the interactions between the ACE2 receptor and S-protein RBD interface are critical for the cellular entry of the virus, we wondered if there were natural ACE2 variations that decrease or increase its affinity to the S-protein RBD that may protect or render individuals more susceptible to the virus. Consistent with this possibility, a saturation mutagenesis screen of select ACE2 PD residues identified variants that showed enhanced or decreased binding to S-protein (Procko, 2020) .
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