Author: Daniel J Butler; Christopher Mozsary; Cem Meydan; David C Danko; Jonathan Foox; Joel Rosiene; Alon Shaiber; Ebrahim Afshinnekoo; Matthew MacKay; Fritz J Sedlazeck; Nikolay A Ivanov; Maria A Sierra; Diana Pohle; Michael Zeitz; Vijendra Ramlall; Undina Gisladottir; Craig D Westover; Krista Ryon; Benjamin Young; Chandrima Bhattacharya; Phyllis Ruggiero; Bradley W Langhorst; Nathan A Tanner; Justyn Gawrys; Dmitry Meleshko; Dong Xu; Jenny Xiang; Angelika Iftner; Daniela Bezdan; John Sipley; Lin Cong; Arryn Craney; Priya Velu; Ari Melnick; Iman A Hajirasouliha; Thomas Iftner; Mirella Salvatore; Massimo Loda; Lars F Westblade; Shawn Levy; Melissa Cushing; Nicholas P Tatonetti; Marcin Imielinski; Hanna Rennert; Christopher Mason
Title: Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Document date: 2020_4_20
ID: kyoa5gsf_27
Snippet: Down-regulated genes and those with a negative enrichment score (NES) were functionally distinct (Figure 6d ). These included ALAS2, a gene which makes erythroid ALA-synthase (Ajioka et al,. 2006 ) that is found in developing erythroblasts (red blood cells). ALA-synthase plays an important role in the production of heme TRIM2 E3 ubiquitin ligase induced during late erythropoiesis, which indicated a connection to hematological and iron (heme) regu.....
Document: Down-regulated genes and those with a negative enrichment score (NES) were functionally distinct (Figure 6d ). These included ALAS2, a gene which makes erythroid ALA-synthase (Ajioka et al,. 2006 ) that is found in developing erythroblasts (red blood cells). ALA-synthase plays an important role in the production of heme TRIM2 E3 ubiquitin ligase induced during late erythropoiesis, which indicated a connection to hematological and iron (heme) regulation during infection (Figure 6d) . Accordingly, genes in a related biological network were significantly enriched based on Gene Ontology (GO) pathways for iron regulation (q-value =0.002, Supp. Table 4 ). Both the up-regulated and down-regulated gene expression differences in were distinct from those of house-keeping genes (Supp. Figure 11) , which stayed mostly stable during infection.
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