Author: Wenbin Ji; Yibo Luo; Ejaz Ahmad; Song-Tao Liu
Title: Coordination between discrete Mitotic Arrest Deficient 1 (MAD1) domains is required for efficient mitotic checkpoint signaling Document date: 2017_11_1
ID: i4yquw4k_2
Snippet: Two major questions remain unanswered for the model. First, human MAD1 is a mitotic checkpoint protein of 718 amino acid residues but the formation of a 2:2 heterotetramer with C-MAD2 involves only its MAD2 interaction motif (MIM, 485-584 residues) especially a disordered loop spanning 530-550 residues (Fig. 1a) (11) . However, some earlier and recent experiments argued for functional importance of the C-terminal domain of MAD1 (585-718 residues,.....
Document: Two major questions remain unanswered for the model. First, human MAD1 is a mitotic checkpoint protein of 718 amino acid residues but the formation of a 2:2 heterotetramer with C-MAD2 involves only its MAD2 interaction motif (MIM, 485-584 residues) especially a disordered loop spanning 530-550 residues (Fig. 1a) (11) . However, some earlier and recent experiments argued for functional importance of the C-terminal domain of MAD1 (585-718 residues, MAD1 CTD ) in maintaining the mitotic checkpoint (12) (13) (14) (15) (16) (17) (18) .
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