A Weak Supervision-based Framework for Automatic Lung Cancer Classification on Whole Slide Image.

Xu, Xiaowei; Hou, Runping; Zhao, Wangyuan; Teng, Haohua; Sun, Jianqi; Zhao, Jun

Classification of normal lung tissue, lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) by pathological images is significant for clinical diagnosis and treatment. Due to the large scale of pathological images and the absence of definitive morphological features between LUAD and LUSC, it is time-consuming, laborious and challenging for pathologists to analyze the microscopic histopathology slides by visual observation. In this paper, a pixel-level annotation-free framework was proposed to classify normal tissue, LUAD and LUSC slides. This framework can be divided into two stages: tumor classification and localization, and subtype classification. In the first stage, EM-CNN was utilized to distinguish tumor slides from normal tissue slides and locate the discriminative regions for subsequent analysis with only image-level labels provided. In the second stage, a multi-scale network was proposed to improve the accuracy of subtype classification. This method achieved an AUC of 0.9978 for tumor classification and an AUC of 0.9684 for subtype classification, showing its superiority in lung pathological image classification compared with other methods.