Host, Viral, and Environmental Transcriptome Profiles of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Daniel J Butler; Christopher Mozsary; Cem Meydan; David C Danko; Jonathan Foox; Joel Rosiene; Alon Shaiber; Ebrahim Afshinnekoo; Matthew MacKay; Fritz J Sedlazeck; Nikolay A Ivanov; Maria A Sierra; Diana Pohle; Michael Zeitz; Vijendra Ramlall; Undina Gisladottir; Craig D Westover; Krista Ryon; Benjamin Young; Chandrima Bhattacharya; Phyllis Ruggiero; Bradley W Langhorst; Nathan A Tanner; Justyn Gawrys; Dmitry Meleshko; Dong Xu; Jenny Xiang; Angelika Iftner; Daniela Bezdan; John Sipley; Lin Cong; Arryn Craney; Priya Velu; Ari Melnick; Iman A Hajirasouliha; Thomas Iftner; Mirella Salvatore; Massimo Loda; Lars F Westblade; Shawn Levy; Melissa Cushing; Nicholas P Tatonetti; Marcin Imielinski; Hanna Rennert; Christopher Mason

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.20.048066 doi: bioRxiv preprint Supplemental Figure 12 . ACEI Multivariate and Comparative Analyses. (a) Regression coefficients for variables indicating exposure/history of exposure to ACE inhibitors for each of the three cohort comparisons: (left) test outcome in a cohort of patients suspected of SARS-CoV-2 infection, (middle) requirement of mechanical respiration in patients who tested positive, (right) mortality in patients who tested positive. Univariate analyses are shown as red circles. The green triangles coefficients are when correcting for age, sex, and baseline IL-6 levels take upon admission. The blue squares are from a model that includes age, sex, and IL-6 as well as comorbidities including CAD/CHD, diabetes, obesity, and self-reported race and ethnicity. (b) Comparison of the effects of different ACE inhibitors. We directly compared the effects of specific ACE inhibitors among those patients with evidence of exposure to ACE inhibitors. We found two significant associations: benazepril was significantly associated with higher mortality (HR=2.37 95%CI 1.05-5.35, p=3.70E-02) and trandolapril was associated with requirement of mechanical ventilation (HR=15.85 95% CI: 2.11-119.08, p=7.25E-03). N.D. indicates that a result was not displayed due to low sample size and, therefore, very large errors.