Author: Cody S. Nelson; Tori Huffman; Eduardo Cisneros de la Rosa; Guanhua Xie; Nathan Vandergrift; Robert F. Pass; Justin Pollara; Sallie R. Permar
Title: HCMV glycoprotein B subunit vaccine efficacy was mediated by non-neutralizing antibody effector functions Document date: 2018_1_11
ID: bxqc9a7f_35
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/246884 doi: bioRxiv preprint 14 important neutralizing epitopes were either: 1) inadequately exposed to the immune system on 278 the protein immunogen, or 2) that their post-fusion conformation presented via the protein 279 immunogen did not .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/246884 doi: bioRxiv preprint 14 important neutralizing epitopes were either: 1) inadequately exposed to the immune system on 278 the protein immunogen, or 2) that their post-fusion conformation presented via the protein 279 immunogen did not accurately mimic the pre-fusion conformation on the viral envelope, as has 280 been described for HSV-1 gB (49).
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