Selected article for: "current pandemic and different set"
Author: Austin Nguyen; Julianne K David; Sean K Maden; Mary A Wood; Benjamin R Weeder; Abhinav Nellore; Reid F Thompson
Title: Human leukocyte antigen susceptibility map for SARS-CoV-2
  • Document date: 2020_3_26
    • ID: k3y8tpps_12
    Snippet: Given the global nature of the current COVID-19 pandemic, we sought to describe population-level distributions of the HLA alleles best (and least) able to generate a repertoire of SARS-CoV-2 epitopes in support of a T-cell based immune response. While we present global maps of individual HLA allele frequencies for the full set of 145 different alleles studied herein (Appendix 2), we specifically highlight the global distributions of the three bes.....
    Document: Given the global nature of the current COVID-19 pandemic, we sought to describe population-level distributions of the HLA alleles best (and least) able to generate a repertoire of SARS-CoV-2 epitopes in support of a T-cell based immune response. While we present global maps of individual HLA allele frequencies for the full set of 145 different alleles studied herein (Appendix 2), we specifically highlight the global distributions of the three best-presenting (A*02:02, B*15:03, C*12:03) and three of the worst-presenting (A*25:01, B*46:01, C*01:02) HLA-A, -B, and -C alleles ( Figure 5 ). Note that all allelic frequencies are aggregated by country, but implicitly reflect the distribution of HLA data available on the Allele Frequency Net Database (52) . 19 .1%, and 7.9% of presentable epitopes, respectively). Conversely, the rightmost panels show the global allele frequency distributions by country for three representative alleles (HLA-A*25:01, HLA-B*46:01, and HLA-C*01:02) with the least predicted epitope presentation from the SARS-CoV-2 proteome (0.2%, 0%, 0% of presentable epitopes, respectively). Heatmap color corresponds to the individual HLA allele frequency within each country ranging from least (white/yellow) to most (red) frequent as indicated in the legend below each map.

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