Author: Longlong Si; Haiqing Bai; Melissa Rodas; Wuji Cao; Crystal Yur Oh; Amanda Jiang; Atiq Nurani; Danni Y Zhu; Girija Goyal; Sarah Gilpin; Rachelle Prantil-Baun; Donald E. Ingber
Title: Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics Document date: 2020_4_14
ID: mrgw2mnx_11
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.13.039917 doi: bioRxiv preprint Variations in secretion of proinflammatory mediators in the human lung airway may contribute to differences in pathogenesis observed for different influenza virus strains, and analysis of cytokine levels that drive 'cytokine storms' can help clinicians assess the disease severity. Thus, we compared the inna.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.13.039917 doi: bioRxiv preprint Variations in secretion of proinflammatory mediators in the human lung airway may contribute to differences in pathogenesis observed for different influenza virus strains, and analysis of cytokine levels that drive 'cytokine storms' can help clinicians assess the disease severity. Thus, we compared the innate immune responses of the human Airway Chip to infection with three patient-derived influenza virus strains with different virulence: NL/09 (H1N1), Pan/99 (H3N2), and A/HongKong/156/1997 (HK/97; H5N1). When chips were infected with H3N2 and H5N1 viruses that are known to produce more severe clinical symptoms than H1N1 in patients, we found that they also stimulated production of higher levels of cytokines and chemokines, and the most virulent H5N1 induced the highest concentrations (Fig. 2E) . These results mirror the clinical finding that patients infected with H5N1 have increased serum concentrations of these inflammatory factors relative to those with H1N1 or H3N2, which significantly contributes to disease pathogenesis 16 .
Search related documents:
Co phrase search for related documents- chemokine cytokine and cytokine storm: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- chemokine cytokine and cytokine storm drive: 1, 2
- chemokine cytokine and disease severity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- chemokine cytokine and high level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- chemokine cytokine high level and cytokine level: 1, 2
- chemokine cytokine high level and high level: 1, 2
- clinical finding and cytokine storm: 1, 2
- clinical finding and disease severity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- clinical finding and high level: 1, 2, 3, 4
- clinical symptom and cytokine storm: 1, 2
- clinical symptom and disease severity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- clinical symptom and disease severity assess: 1
- clinical symptom and high level: 1, 2
- cytokine level and disease severity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- cytokine level and high level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- cytokine storm and disease severity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cytokine storm and disease severity assess: 1, 2, 3, 4, 5
- cytokine storm and high concentration: 1, 2, 3, 4
- cytokine storm and high level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
Co phrase search for related documents, hyperlinks ordered by date