Author: Timothy A. Dinh; Ramja Sritharan; F. Donelson Smith; Adam B. Francisco; Rosanna K. Ma; Rodica P. Bunaciu; Matt Kanke; Charles G. Danko; Andrew P. Massa; John D. Scott; Praveen Sethupathy
Title: Hotspots of aberrant enhancer activity in fibrolamellar carcinoma reveal molecular mechanisms of oncogenesis and intrinsic drug resistance Document date: 2020_1_18
ID: bf4qpsy7_34
Snippet: Integrative analyses of ChRO-seq and RNA-seq data identified 16 high-confidence candidate oncogenes in FLC. Some of these genes, including LINC00473 and CA12 have been characterized in other cancers previously. LINC00473 is known to be overexpressed in FLC (Dinh et al., 2017) and other cancers (Chen et al., 2016 (Chen et al., , 2018 Shi et al., 2017) , and promotes chemotherapeutic resistance in colon cancer and head and neck squamous cell carcin.....
Document: Integrative analyses of ChRO-seq and RNA-seq data identified 16 high-confidence candidate oncogenes in FLC. Some of these genes, including LINC00473 and CA12 have been characterized in other cancers previously. LINC00473 is known to be overexpressed in FLC (Dinh et al., 2017) and other cancers (Chen et al., 2016 (Chen et al., , 2018 Shi et al., 2017) , and promotes chemotherapeutic resistance in colon cancer and head and neck squamous cell carcinoma (Han et al., 2018) . CA12 has been linked to drug resistance in multiple cancer types (Boyd et al., 2017; Doyen et al., 2013; Kopecka et al., 2016) and we have previously demonstrated that it is overexpressed in FLC (Dinh et al., 2017) . Other genes, including SLC16A14 and FAM19A5, are relatively understudied and merit deeper investigation.
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