Selected article for: "broad range and disease severity"
Author: Schroeder, Maria; Schaumburg, Berfin; Mueller, Zacharias; Parplys, Ann; Jarczak, Dominik; Roedl, Kevin; Nierhaus, Axel; de Heer, Geraldine; Grensemann, Joern; Schneider, Bettina; Stoll, Fabian; Bai, Tian; Jacobsen, Henning; Zickler, Martin; Stanelle-Bertram, Stephanie; Klaetschke, Kristin; Renné, Thomas; Meinhardt, Andreas; Aberle, Jens; Hiller, Jens; Peine, Sven; Kreienbrock, Lothar; Klingel, Karin; Kluge, Stefan; Gabriel, Guelsah
Title: High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study
  • Cord-id: vb1pwvsq
  • Document date: 2021_9_14
    • ID: vb1pwvsq
    Snippet: Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. In this study, we analysed sex hormone levels (estradiol and testosterone) of male and female COVID-19 patients (n = 50) admitted to an intensive care unit (ICU) in comparison to control non-COVID-19 patients at the ICU (n = 42), non-COVID-19 patients with the most prevalent comorbidity (coronary hea
    Document: Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. In this study, we analysed sex hormone levels (estradiol and testosterone) of male and female COVID-19 patients (n = 50) admitted to an intensive care unit (ICU) in comparison to control non-COVID-19 patients at the ICU (n = 42), non-COVID-19 patients with the most prevalent comorbidity (coronary heart diseases) present within the COVID-19 cohort (n = 39) and healthy individuals (n = 50). We detected significantly elevated estradiol levels in critically ill male COVID-19 patients compared to all control cohorts. Testosterone levels were significantly reduced in critically ill male COVID-19 patients compared to control cohorts. No statistically significant differences in sex hormone levels were detected in critically ill female COVID-19 patients, albeit similar trends towards elevated estradiol levels were observed. Linear regression analysis revealed that among a broad range of cytokines and chemokines analysed, IFN-γ levels are positively associated with estradiol levels in male and female COVID-19 patients. Furthermore, male COVID-19 patients with elevated estradiol levels were more likely to receive ECMO treatment. Thus, we herein identified that disturbance of sex hormone metabolism might present a hallmark in critically ill male COVID-19 patients.

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