Selected article for: "current state and knowledge current state"

Author: Agrati, Chiara; Sacchi, Alessandra; Tartaglia, Eleonora; Vergori, Alessandra; Gagliardini, Roberta; Scarabello, Alessandra; Bibas, Michele
Title: The Role of P-Selectin in COVID-19 Coagulopathy: An Updated Review
  • Cord-id: vq4cqupn
  • Document date: 2021_7_26
  • ID: vq4cqupn
    Snippet: In severe COVID-19, which is characterized by blood clots and neutrophil-platelet aggregates in the circulating blood and different tissues, an increased incidence of cardiovascular complications and venous thrombotic events has been reported. The inflammatory storm that characterizes severe infections may act as a driver capable of profoundly disrupting the complex interplay between platelets, endothelium, and leukocytes, thus contributing to the definition of COVID-19-associated coagulopathy.
    Document: In severe COVID-19, which is characterized by blood clots and neutrophil-platelet aggregates in the circulating blood and different tissues, an increased incidence of cardiovascular complications and venous thrombotic events has been reported. The inflammatory storm that characterizes severe infections may act as a driver capable of profoundly disrupting the complex interplay between platelets, endothelium, and leukocytes, thus contributing to the definition of COVID-19-associated coagulopathy. In this frame, P-selectin represents a key molecule expressed on endothelial cells and on activated platelets, and contributes to endothelial activation, leucocyte recruitment, rolling, and tissue migration. Briefly, we describe the current state of knowledge about P-selectin involvement in COVID-19 pathogenesis, its possible use as a severity marker and as a target for host-directed therapeutic intervention.

    Search related documents:
    Co phrase search for related documents
    • abstract title and acute respiratory distress syndrome: 1
    • abstract title and acute respiratory distress syndrome pneumonia: 1
    • abstract title and admission time: 1
    • abstract title and low molecular: 1
    • abstract title and low molecular weight: 1
    • abstract title and low molecular weight heparin: 1
    • activation indicator and acute phase: 1