Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_25
Snippet: to public health of the past century (D. Wu et al., 2020) . Morbidity and mortality data make it clear that age, smoking status and multiple preexisting conditions greatly increase the frequency of serious illness and death . There is an abundance of data from model systems and humans that age and conditions of metabolic stress including obesity and type 2 diabetes (Trammell, Weidemann, et al., 2016) , smoking (Kunzi & Holt, 2019) , heart failure.....
Document: to public health of the past century (D. Wu et al., 2020) . Morbidity and mortality data make it clear that age, smoking status and multiple preexisting conditions greatly increase the frequency of serious illness and death . There is an abundance of data from model systems and humans that age and conditions of metabolic stress including obesity and type 2 diabetes (Trammell, Weidemann, et al., 2016) , smoking (Kunzi & Holt, 2019) , heart failure (Diguet et al., 2018) , nerve damage (Liu et al., 2018) and central brain injury (Vaur et al., 2017 ) challenge the NAD system in multiple affected tissues. Those data and the work establishing the significance of PARPs and CARH in CoV infection prompted us to consider whether NAD status might be a component of innate immunity.
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