Author: Tan, Mingkai; Liu, Yanxia; Zhou, Ruiping; Deng, Xilong; Li, Fang; Liang, Kaiyan; Shi, Yaling
Title: Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China Cord-id: gts8jtae Document date: 2020_5_27
ID: gts8jtae
Snippet: Coronavirus disease 2019 (COVIDâ€19) is a respiratory disorder caused by the highly contagious SARSâ€CoVâ€2. The immunopathological characteristics of COVIDâ€19 patients, either systemic or local, have not been thoroughly studied. In the present study, we analyzed both the changes in the number of various immune cell types as well as cytokines important for immune reactions and inflammation. Our data indicate that patients with severe COVIDâ€19 exhibited an overall decline of lymphocytes in
Document: Coronavirus disease 2019 (COVIDâ€19) is a respiratory disorder caused by the highly contagious SARSâ€CoVâ€2. The immunopathological characteristics of COVIDâ€19 patients, either systemic or local, have not been thoroughly studied. In the present study, we analyzed both the changes in the number of various immune cell types as well as cytokines important for immune reactions and inflammation. Our data indicate that patients with severe COVIDâ€19 exhibited an overall decline of lymphocytes including CD4+ and CD8+ T cells, B cells, and NK cells. The number of immunosuppressive regulatory T cells was moderately increased in patients with mild COVIDâ€19. ILâ€6, ILâ€10, and Câ€reactive protein were remarkably upâ€regulated in patients with severe COVIDâ€19. In conclusion, our study shows that the comprehensive decrease of lymphocytes, the elevation of ILâ€6, ILâ€10, and Câ€reactive protein are reliable indicators of severe COVIDâ€19.
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